Associations between executive function impairment and biochemical abnormalities in bipolar disorder with suicidal ideation

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:18

This study aimed to assess alterations of execution function and biochemical metabolism in BD with SI, in BD without SI, and in healthy controls. The associations between execution function and biochemical metabolism in the two BD patient groups were also been studied.

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Na⁺, K⁺-ATPase Signaling and Bipolar Disorder

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:17

Although in past decades the "monoamine hypothesis" has dominated our understanding of both the pathophysiology of depressive disorders and the action of pharmacological treatments, recent studies focus on the involvement of additional neurotransmitters/neuromodulators systems and cellular processes in BD. Here, evidence for the participation of Na⁺, K⁺-ATPase and its endogenous regulators, the endogenous cardiac steroids (ECS), in the etiology of BD is reviewed.

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The impact of COMT polymorphisms on cognition in Bipolar Disorder

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:16

Cognitive deficits represent a core feature of Bipolar Disorder. The dopamine system is considered fundamental for cognitive functions relying on prefrontal cortex, such as attention and executive functions. 

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Matthew Breuer, an Associate Marriage & Family Therapist, has Bipolar Type 1 himself and focuses on helping others with mood disorders. Explore this site for more information, and contact him for support.

Clinical Repetitive Transcranial Magnetic Stimulation

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:14

Repetitive transcranial magnetic stimulation (rTMS) is being investigated for psychiatric disorders such as posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), and both phases of bipolar disorder. Case series, open trials, and randomized controlled studies have demonstrated preliminary support for treating PTSD with rTMS alone as well as with rTMS combined with psychotherapy. 

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Older Men with Bipolar Disorder Diagnosed in Early and Later Life: Physical Health Morbidity and General Hospital Service Use

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:13

 

Older men with BD have more frequent contact with general hospital services over time than men without BD, independent of age, pre-existing medical morbidities and age at the time of diagnosis of BD.

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Matthew Breuer, an Associate Marriage & Family Therapist, has Bipolar Type 1 himself and focuses on helping others with mood disorders. Explore this site for more information, and contact him for support.

More assortative mating in US compared to European parents and spouses of patients with bipolar disorder: implications for psychiatric illness in the offspring

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:10

The effect of assortative mating on offspring is often not considered. Here, we present data on illness in the spouse and the parents of patients with bipolar disorder as they affect illness in the offspring. A history of psychiatric illness (depression, bipolar disorder, suicide attempt, alcohol abuse, drug abuse, and “other” illness) was elicited for the parents, spouse, and the offspring of 968 patients with bipolar disorder (540 of whom had children) who gave informed consent for participation in a treatment outcome network. 

C-reactive protein and response to lurasidone in patients with bipolar depression

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:08

Prior studies suggest that the inflammatory biomarker c-reactive protein (CRP) holds promise for predicting antidepressant response in patients with major depressive disorder. The objective of this study was to evaluate whether CRP might similarly predict antidepressant responses to lurasidone in patients with bipolar I depression. 

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Aggression among 216 patients with a first-psychotic episode of bipolar I disorder

Submitted by matthewbreuer on Wed, 08/15/2018 - 22:05

Among first-major episode BD-I patients with psychotic features, recent serious aggression towards others was identified in 10.6%. The odds of aggression increased by 4.9-times in association with a recent suicide attempt, more than 3-times with alcohol-abuse or learning disability, and by 2.6-times if the episode polarity was manic.

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The use of (newer) antipsychotics in bipolar inpatients over a 17-year observation period

Submitted by matthewbreuer on Wed, 08/15/2018 - 21:59

Antipsychotics (AP) are commonly used in the treatment of bipolar disorder. They cover a broad spectrum of indications including acute psychotic, manic and depressive symptoms, and maintenance treatment. This study evaluates the changes in prescribing patterns of first-generation antipsychotics (FGA) and second-generation AP at Innsbruck University Hospital for the treatment of bipolar inpatients between 1999 and 2016. 

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Reward and Punishment Sensitivity and Emotion Regulation Processes Differentiate Bipolar and Unipolar Depression

Submitted by matthewbreuer on Wed, 08/01/2018 - 23:01

Bipolar disorder (BD) and major depressive disorder (MDD) cannot be reliably differentiated by depression symptom expression alone, suggesting a need to identify processes that may more effectively differentiate the two disorders. 

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Matthew Breuer, an Associate Marriage & Family Therapist, has Bipolar Type 1 himself and focuses on helping others with mood disorders. Explore this site for more information, and contact him for support.